VHL and ELOC

Number of citations of the paper that reports this interaction (PubMedID 7660130)
155

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		VHL	ELOC
Description		von Hippel-Lindau tumor suppressor	elongin C
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane VCB Complex	Nucleoplasm Cytosol Elongin Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of JAK-STAT Cascade Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Renal cell carcinoma von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Interacting Genes		103 interacting genes: ACTB AKT1 APP AR AURKA CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CDKN2A CERKL CHEK2 CLU COL4A2 CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR FKBP8 FLNA FN1 GHET1 H1-2 H2BC13 H4-16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSPA5 HSPA8 IKBKB JADE1 KIF2C KIF3A KLF4 LANCL1 MAP1LC3B MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PIAS4 PLD1 PLD2 POLR2G PPP5C PRDX1 PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TPT1 TRIM28 UBE2D1 UBE2D2 UBE2I USP20 USP33 USP9X UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	47 interacting genes: CBX5 CENPC COMMD1 CPTP CUL2 CUL3 CYP2J2 ECT2 EFNB3 ELOA2 ELOA3 ELOB EPOR GDAP1 GHR HNF4G ID2 INSIG1 JTB KRT8 LRRC41 LY96 MCM7 MED8 METTL21C MRAS NAA25 NFKBIA NOTCH4 NRCAM PEX2 PRAME RCAN2 RNF7 RPL7 SAT2 SERTAD1 SKAP1 SOCS1 SOCS3 SOCS6 UBC UBE2W USP33 VHL WNT7B ZYG11B
Entrez ID		7428	6921
HPRD ID		01905	02875
Ensembl ID		ENSG00000134086	ENSG00000154582
Uniprot IDs		A0A024R2F2 A0A0S2Z4K1 P40337	A0A024R7Y5 Q15369
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F	1LM8 1LQB 1VCB 2C9W 2IZV 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7R 6R7F 6R7H 6R7N
Enriched GO Terms of Interacting Partners?
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