USP4 and PDK1

Number of citations of the paper that reports this interaction (PubMedID 22347420)
10

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		USP4	PDK1
Description		ubiquitin specific peptidase 4	pyruvate dehydrogenase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface	Glucose Metabolic Process Protein Phosphorylation Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Glucose Homeostasis Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Pyruvate Dehydrogenase Activity
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs			4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic Acid
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908 25082827)	Blood protein levels ( 28240269) Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		47 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A CIAO2B HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	15 interacting genes: AKT1 COL6A1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 USP4 XRCC6 YWHAQ
Entrez ID		7375	5163
HPRD ID		04598	03954
Ensembl ID		ENSG00000114316	ENSG00000152256
Uniprot IDs		A0A024R2X6 A1LPW7 Q08AK7 Q13107	B7Z7N6 Q15118
PDB IDs		2Y6E 5CTR	2Q8F 2Q8G 2Q8H
Enriched GO Terms of Interacting Partners?
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