USP4 and ATP1B3

Number of citations of the paper that reports this interaction (PubMedID 23022198)
4

Data Source:
BioGRID (two hybrid)

		USP4	ATP1B3
Description		ubiquitin specific peptidase 4	ATPase Na+/K+ transporting subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Plasma Membrane	Cell Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Sperm Flagellum Melanosome Extracellular Exosome
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding Metal Ion Binding	ATPase Activator Activity Sodium:potassium-exchanging ATPase Activity Cation-transporting ATPase Activity ATPase Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface	Cellular Sodium Ion Homeostasis Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Stabilization Leukocyte Migration Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Basigin interactions Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 28898252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908 25082827)	Blond vs. brown/black hair color ( 30531825) Pulse pressure ( 27841878) Red cell distribution width ( 27863252 28957414) Testicular germ cell tumor ( 26503584) Total hippocampal volume ( 30279459) Waist-hip ratio ( 28552196)
Interacting Genes		47 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A CIAO2B HDAC2 HUWE1 IGKV2D-29 IRF4 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28	10 interacting genes: BAALC BARD1 BRCA1 MYCBP2 NLRP3 PAXIP1 PEA15 TRIM14 UPF2 USP4
Entrez ID		7375	483
HPRD ID		04598	03521
Ensembl ID		ENSG00000114316	ENSG00000069849
Uniprot IDs		A0A024R2X6 A1LPW7 Q08AK7 Q13107	P54709
PDB IDs		2Y6E 5CTR
Enriched GO Terms of Interacting Partners?
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