TUBG1 and DDX41

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		TUBG1	DDX41
Description		tubulin gamma 1	DEAD-box helicase 41
Image
GO Annotations	Cellular Component	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Nucleus Cytoplasm Centrosome Centriole Spindle Polar Microtubule Cytosol Microtubule Cytoplasmic Microtubule Cell Leading Edge Ciliary Basal Body Apical Part Of Cell Recycling Endosome Non-motile Cilium	Nucleus Spliceosomal Complex Endoplasmic Reticulum Cytosol Membrane Catalytic Step 2 Spliceosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Identical Protein Binding	DNA Binding RNA Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Microtubule Nucleation Mitotic Spindle Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasmic Microtubule Organization Ciliary Basal Body-plasma Membrane Docking	MRNA Splicing, Via Spliceosome Apoptotic Process Cell Proliferation Cell Differentiation Positive Regulation Of Type I Interferon Production Cellular Response To Interferon-beta Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs		Vinblastine
Diseases
GWAS			Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		29 interacting genes: APP BRCA1 CENPJ CNTN2 CUL4A DDX41 IKBKG KIF14 KRT18 KRT19 MARK4 NAPG NDE1 OLA1 PCNT PIK3R1 PLK1 PXN RACGAP1 RACK1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4	5 interacting genes: CEP70 CHAF1A KLC2 SIAH1 TUBG1
Entrez ID		7283	51428
HPRD ID		01853	10490
Ensembl ID		ENSG00000131462	ENSG00000183258
Uniprot IDs		P23258	B3KRK2 Q9UJV9
PDB IDs		1Z5V 1Z5W 3CB2	2P6N 5GVR 5GVS 5H1Y
Enriched GO Terms of Interacting Partners?
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