TNNC2 and TNNI3

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		TNNC2	TNNI3
Description		troponin C2, fast skeletal type	troponin I3, cardiac type
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Cell Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Binding Actin Filament Binding	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction Ion homeostasis
Drugs		Felodipine Calcium Octylphenoxy polyethoxyethanol	N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS
Interacting Genes		3 interacting genes: PIK3R3 TNNI2 TNNI3	18 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		7125	7137
HPRD ID		08929	11769
Ensembl ID		ENSG00000101470	ENSG00000129991
Uniprot IDs		C9J7T9 P02585	P19429 Q6FGX2
PDB IDs			1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6MV3
Enriched GO Terms of Interacting Partners?
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