TNNI3 and TNNI3K

Number of citations of the paper that reports this interaction (PubMedID 12721663)
15

Data Source:
HPRD (two hybrid, in vivo)

		TNNI3	TNNI3K
Description		troponin I3, cardiac type	TNNI3 interacting kinase
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GO Annotations	Cellular Component	Cell Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Regulation Of Heart Rate Protein Phosphorylation Regulation Of Cardiac Muscle Contraction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Cardiac Conduction
Pathways		Striated Muscle Contraction Ion homeostasis
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS			BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26426971 23669352 28892062 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Childhood body mass index ( 26604143) Hip circumference ( 25673412) Menarche (age at onset) ( 27182965 25231870) Mental health study participation (completed survey) ( 31263887) Obesity ( 23563607) Parental longevity (combined parental age at death) ( 29227965) Pubertal anthropometrics ( 23449627) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		18 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	7 interacting genes: ACTA1 ACTC1 AIP FABP3 HADHB MYBPC3 TNNI3
Entrez ID		7137	51086
HPRD ID		11769	18208
Ensembl ID		ENSG00000129991	ENSG00000116783
Uniprot IDs		P19429 Q6FGX2	Q59H18
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6MV3	4YFF 4YFI 6B5J
Enriched GO Terms of Interacting Partners?
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