TLR1 and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 11584270)
136

Data Source:
HPRD (in vivo)

		TLR1	HSP90B1
Description		toll like receptor 1	heat shock protein 90 beta family member 1
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Membrane Raft	Extracellular Region Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Response To Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Interleukin-8 Secretion	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin 1-Methoxy-2-(2-Methoxyethoxy)Ethane N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 30929738 27182965 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	28 interacting genes: APOB ASGR1 BIRC2 CACYBP CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 ESR1 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTPN11 SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11
Entrez ID		7096	7184
HPRD ID		03119	01860
Ensembl ID		ENSG00000174125	ENSG00000166598
Uniprot IDs		Q15399	P14625 V9HWP2
PDB IDs		1FYV 2Z7X 6NIH	4NH9
Enriched GO Terms of Interacting Partners?
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