TLR1 and TLR2

Number of citations of the paper that reports this interaction (PubMedID 12077222)
320

Data Source:
HPRD (in vivo)

		TLR1	TLR2
Description		toll like receptor 1	toll like receptor 2
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Membrane Raft	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Phagocytic Vesicle Membrane Intrinsic Component Of Plasma Membrane Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Cell Projection Cell Body Membrane Raft
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Receptor Activity Protein Binding Toll-like Receptor Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Triacyl Lipopeptide Binding Identical Protein Binding Peptidoglycan Binding Protein-containing Complex Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Macrophage Activation Detection Of Triacyl Bacterial Lipopeptide Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Innate Immune Response Positive Regulation Of Interleukin-6 Biosynthetic Process Cellular Response To Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of Interleukin-8 Secretion	Response To Hypoxia Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway Cytokine Secretion Involved In Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Leukotriene Metabolic Process Apoptotic Process Inflammatory Response Immune Response Signal Transduction I-kappaB Phosphorylation Learning Negative Regulation Of Cell Proliferation Response To Toxic Substance Positive Regulation Of Gene Expression Microglia Development Positive Regulation Of Wnt Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Central Nervous System Myelin Formation Response To Progesterone Interleukin-10 Production Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Insulin Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Triacyl Bacterial Lipopeptide Detection Of Diacyl Bacterial Lipopeptide Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Nitric Oxide Metabolic Process Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Negative Regulation Of Synapse Assembly Response To Fatty Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Cellular Response To Interferon-gamma Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways		ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand	ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system
Drugs			Lyme disease vaccine (recombinant OspA) S-(Dimethylarsenic)Cysteine Golotimod Tuberculin Purified Protein Derivative
Diseases
GWAS		Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 30929738 27182965 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Composite immunoglobulin trait (IgG/IgM) ( 28628107) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Body fat mass ( 28552196)
Interacting Genes		9 interacting genes: DHX36 HSP90B1 HSPD1 TLR10 TLR2 TLR4 TLR5 TLR9 TRAP1	19 interacting genes: CD14 EGFR HMGB1 HRAS HSP90B1 IRAK1 LY96 MAPK8IP3 MYD88 PIK3R1 RAC1 RIPK2 TICAM1 TIRAP TLR1 TLR10 TLR6 TOLLIP TRIP6
Entrez ID		7096	7097
HPRD ID		03119	04323
Ensembl ID		ENSG00000174125	ENSG00000137462
Uniprot IDs		Q15399	A0A0S2Z4S4 B3KWR9 O60603
PDB IDs		1FYV 2Z7X 6NIH	1FYW 1FYX 1O77 2Z7X 2Z80 6NIG
Enriched GO Terms of Interacting Partners?
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