C1QBP and HRK

Number of citations of the paper that reports this interaction (PubMedID 15031724)
31

Data Source:
HPRD (in vitro, two hybrid)

		C1QBP	HRK
Description		complement C1q binding protein	harakiri, BCL2 interacting protein
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Mitochondrion Integral Component Of Membrane
	Molecular Function	Complement Component C1q Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Translation Activator Activity Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Apoptotic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs		Hyaluronic acid Copper
Diseases
GWAS		Rheumatoid arthritis ( 30423114 24390342)	Alzheimer's disease (age of onset) ( 22005931) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)
Interacting Genes		26 interacting genes: C1QA CEBPA COIL EXOSC6 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK MAPK1 MAPK3 MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG	7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1
Entrez ID		708	8739
HPRD ID		03168	04581
Ensembl ID		ENSG00000108561	ENSG00000135116
Uniprot IDs		Q07021	O00198
PDB IDs		1P32 3RPX	2L58 2L5B
Enriched GO Terms of Interacting Partners?
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