HRK and BCL2L2

Number of citations of the paper that reports this interaction (PubMedID 15694340)
667

Data Source:
BioGRID (unspecified method)
HPRD (in vitro)

		HRK	BCL2L2
Description		harakiri, BCL2 interacting protein	BCL2 like 2
Image
GO Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs			Navitoclax
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain structure ( 22504417) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) HATA volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal tail volume ( 30279459) Hippocampal volume ( 28098162 22504421) Presubiculum volume ( 30279459) Presubiculum volume (corrected for total hippocampal volume) ( 30279459) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Total hippocampal volume ( 30279459)	Height ( 28552196)
Interacting Genes		7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	17 interacting genes: BAD BAX BBC3 BCL2L11 BID BIK BMF BNIP3 FATE1 HRK KASH5 LMNA PPP1CA S100B TCF4 TEX11 TP53
Entrez ID		8739	599
HPRD ID		04581	03569
Ensembl ID		ENSG00000135116	ENSG00000129473
Uniprot IDs		O00198	Q92843
PDB IDs		2L58 2L5B	1MK3 1O0L 1ZY3 2Y6W 4CIM
Enriched GO Terms of Interacting Partners?
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