TDO2 and ZFYVE26

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TDO2	ZFYVE26
Description		tryptophan 2,3-dioxygenase	zinc finger FYVE-type containing 26
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Lysosomal Membrane Centrosome Midbody
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Oxidation-reduction Process Response To Nitroglycerin	Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Regulation Of Cytokinesis
Pathways		Tryptophan catabolism
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 31036433)
Interacting Genes		16 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA MEOX2 MOB1A MOB3C NGB NMNAT1 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26	19 interacting genes: ALAS1 CEP44 GOLGA2 HNRNPC KRT15 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MDFI PNMA1 PNMA5 SPAG5 SSX2IP TADA2A TDO2 TFIP11 TRAF1 USHBP1
Entrez ID		6999	23503
HPRD ID		01847	15734
Ensembl ID		ENSG00000151790	ENSG00000072121
Uniprot IDs		P48775	Q68DK2
PDB IDs		4PW8 5TI9 5TIA 6A4I
Enriched GO Terms of Interacting Partners?
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