ZFYVE26 and TDO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZFYVE26	TDO2
Description		zinc finger FYVE-type containing 26	tryptophan 2,3-dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Centrosome Midbody	Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Double-strand Break Repair Via Homologous Recombination Regulation Of Cytokinesis	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Oxidation-reduction Process Response To Nitroglycerin
Pathways			Tryptophan catabolism
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 31036433)	Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		19 interacting genes: ALAS1 CEP44 GOLGA2 HNRNPC KRT15 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MDFI PNMA1 PNMA5 SPAG5 SSX2IP TADA2A TDO2 TFIP11 TRAF1 USHBP1	16 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA MEOX2 MOB1A MOB3C NGB NMNAT1 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26
Entrez ID		23503	6999
HPRD ID		15734	01847
Ensembl ID		ENSG00000072121	ENSG00000151790
Uniprot IDs		Q68DK2	P48775
PDB IDs			4PW8 5TI9 5TIA 6A4I
Enriched GO Terms of Interacting Partners?
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