TCN2 and PLEKHF2

		TCN2	PLEKHF2
Description		transcobalamin 2	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Lysosomal Lumen	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding Cobalamin Binding Metal Ion Binding	Protein Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Cobalt Ion Transport Cobalamin Metabolic Process Cobalamin Transport	Protein Transport
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective TCN2 causes hereditary megaloblastic anemia Defective CD320 causes methylmalonic aciduria
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Factor VIII levels ( 30586737) Moyamoya disease ( 29273593) Venous thromboembolism ( 31420334) vWF levels ( 30586737)	Radiation response ( 20923822)
Interacting Genes		5 interacting genes: APP CBL PAXIP1 PLEKHF2 RHOU	71 interacting genes: ACY3 AIDA AIMP2 APP APPL1 ARL14EP BEND7 BLOC1S6 BSCL2 CAVIN2 CCDC172 CCDC85B CEP44 CGGBP1 CHIC2 DPPA4 DRAP1 DTX2 DUT ESRP1 FBXO28 FHL3 FOXA1 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HEY1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NKG7 NONO NPM2 PDP1 PEX2 PRDM14 PRKAR1A PRPSAP1 RAB39A RABAC1 RADX RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SPEF1 TBX3 TCN2 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z USF1 ZNF250 ZNF263 ZNF398
Entrez ID		6948	79666
HPRD ID		02037	15147
Ensembl ID		ENSG00000185339	ENSG00000175895
Uniprot IDs		P20062	Q9H8W4
PDB IDs		2BB5 4ZRP 4ZRQ 5NO0 5NP4 5NRP 5NSA
Enriched GO Terms of Interacting Partners?
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