ELOA and ERCC6

Number of citations of the paper that reports this interaction (PubMedID 28292928)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ELOA	ERCC6
Description		elongin A	ERCC excision repair 6, chromatin remodeling factor
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Elongin Complex Site Of DNA Damage	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex Site Of DNA Damage
	Molecular Function	Protein Binding	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter	Single Strand Break Repair DNA Damage Checkpoint Response To Superoxide Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Neurogenesis Neuron Differentiation Neuron Projection Development DNA Duplex Unwinding Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth ATP-dependent Chromatin Remodeling Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Protein Tyrosine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS			Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		25 interacting genes: BRCA1 CBY2 CEP57L1 CEP70 CUL5 ELOB ERCC6 FAM9B GMCL1 HOMEZ JAKMIP2 KRT40 KRTAP10-3 LMNA MDFI MED21 MID2 NINL PLK4 POLR2A RAD54B RAP1A REXO1 SIRPA TRIM54	18 interacting genes: BRCA1 CHEK2 CUL5 ELOA ERCC5 ERCC8 GTF2E2 H2AC4 H2BC3 H3C1 H4C1 PARP1 POLR2A RNF11 TP53 UBC XAB2 XPA
Entrez ID		6924	2074
HPRD ID		02873	00596
Ensembl ID		ENSG00000011007	ENSG00000225830
Uniprot IDs		Q14241	A8K4Q3 P0DP91 Q03468 Q59FF6
PDB IDs		4HFX	4CVO 6A6I
Enriched GO Terms of Interacting Partners?
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