ERCC6 and H2BC3

Number of citations of the paper that reports this interaction (PubMedID 11003660)
116

Data Source:
BioGRID (far western blotting)

		ERCC6	H2BC3
Description		ERCC excision repair 6, chromatin remodeling factor	H2B clustered histone 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex Site Of DNA Damage	Nuclear Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein-containing Complex Binding Protein N-terminus Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Single Strand Break Repair DNA Damage Checkpoint Response To Superoxide Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Neurogenesis Neuron Differentiation Neuron Projection Development DNA Duplex Unwinding Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth ATP-dependent Chromatin Remodeling Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Protein Tyrosine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly Protein Ubiquitination
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		18 interacting genes: BRCA1 CHEK2 CUL5 ELOA ERCC5 ERCC8 GTF2E2 H2AC4 H2BC3 H3C1 H4C1 PARP1 POLR2A RNF11 TP53 UBC XAB2 XPA	23 interacting genes: AKT1 APP CDK1 CDK2 CREBBP DYRK1A EID1 EP300 ERCC6 FANCD2 H2AC4 KAT2B MYB PSMD4 RNF20 RNF8 RPS6KA5 UBR7 UHRF1 USP16 USP36 USP43 USP51
Entrez ID		2074	3018
HPRD ID		00596	07536
Ensembl ID		ENSG00000225830	ENSG00000276410
Uniprot IDs		A8K4Q3 P0DP91 Q03468 Q59FF6	P33778
PDB IDs		4CVO 6A6I	3X1S 3X1U
Enriched GO Terms of Interacting Partners?
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