CNTN2 and CNTNAP2

Number of citations of the paper that reports this interaction (PubMedID 12975355)
74

Data Source:
HPRD (in vitro)

		CNTN2	CNTNAP2
Description		contactin 2	contactin associated protein 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Axon Node Of Ranvier Neuronal Cell Body Myelin Sheath Juxtaparanode Region Of Axon Synapse Anchored Component Of Postsynaptic Membrane	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Paranodal Junction Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon
	Molecular Function	Carbohydrate Binding Identical Protein Binding Protein Self-association Cell-cell Adhesion Mediator Activity	Protein Binding Enzyme Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Axonal Fasciculation Learning Adult Walking Behavior Positive Regulation Of Protein Processing Cerebral Cortex GABAergic Interneuron Migration Central Nervous System Myelination Regulation Of Axon Diameter Receptor Internalization Clustering Of Voltage-gated Potassium Channels Negative Regulation Of Neuron Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Astrocyte Differentiation Positive Regulation Of Adenosine Receptor Signaling Pathway Dendrite Self-avoidance Protein Localization To Juxtaparanode Region Of Axon Establishment Of Protein Localization To Juxtaparanode Region Of Axon Presynaptic Membrane Organization	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Social Behavior Vocal Learning Clustering Of Voltage-gated Potassium Channels Neuron Projection Morphogenesis Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior
Pathways		L1CAM interactions NCAM1 interactions NrCAM interactions
Drugs
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Adventurousness ( 30643258) Blood protein levels ( 30072576 29875488 28240269) Mean platelet volume ( 24026423) Number of sexual partners ( 30643258) Red blood cell count ( 27863252) Schizophrenia ( 30285260)	Age-related hearing impairment ( 24939585) Alzheimer's disease ( 22159054) Alzheimer's disease (late onset) ( 26049409) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD++) ( 31473137) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bipolar disorder and schizophrenia ( 20889312) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488) Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Bone mineral density ( 17903296) Choroid plexus volume ( 31530798) Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes ( 27647854) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Crohn's disease ( 26192919) Diabetic kidney disease ( 26305897) Family history of Alzheimer's disease ( 30617256) Glaucoma ( 30104761) Inflammatory bowel disease ( 26192919) Initial pursuit acceleration ( 29064472) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol x physical activity interaction (1df test) ( 30670697) LDL cholesterol x physical activity interaction (2df test) ( 30670697) Lung function (FEV1/FVC) ( 30061609) Obesity-related traits ( 23251661) QT interval (drug interaction) ( 23459443) Response to radiotherapy in cancer (late toxicity) ( 24785509) Smoking status (heavy vs never) ( 26423011) Ulcerative colitis ( 26192919) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		11 interacting genes: CDK4 CHEK1 CNTN1 CNTNAP2 EGFR L1CAM NCAN NFYB NRCAM TUBG1 VAC14	8 interacting genes: CASK CNTN2 CTR9 EPB41L3 KCNA2 MACF1 MEOX2 ZMIZ1
Entrez ID		6900	26047
HPRD ID		01826	05197
Ensembl ID		ENSG00000184144	ENSG00000174469
Uniprot IDs		A1L3A3 A1ML24 Q02246	A0A090N7T7 B2RCH4 Q9UHC6
PDB IDs		2OM5	5Y4M
Enriched GO Terms of Interacting Partners?
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