CNTNAP2 and ZMIZ1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		CNTNAP2	ZMIZ1
Description		contactin associated protein 2	zinc finger MIZ-type containing 1
Image
GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Paranodal Junction Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Enzyme Binding	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Transcription Coactivator Activity Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity SMAD Binding SUMO Ligase Activity
	Biological Process	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Social Behavior Vocal Learning Clustering Of Voltage-gated Potassium Channels Neuron Projection Morphogenesis Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Vitellogenesis Cell Aging Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Protein Sumoylation Positive Regulation Of T Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Age-related hearing impairment ( 24939585) Alzheimer's disease ( 22159054) Alzheimer's disease (late onset) ( 26049409) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD++) ( 31473137) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bipolar disorder and schizophrenia ( 20889312) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488) Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Bone mineral density ( 17903296) Choroid plexus volume ( 31530798) Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes ( 27647854) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Crohn's disease ( 26192919) Diabetic kidney disease ( 26305897) Family history of Alzheimer's disease ( 30617256) Glaucoma ( 30104761) Inflammatory bowel disease ( 26192919) Initial pursuit acceleration ( 29064472) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol x physical activity interaction (1df test) ( 30670697) LDL cholesterol x physical activity interaction (2df test) ( 30670697) Lung function (FEV1/FVC) ( 30061609) Obesity-related traits ( 23251661) QT interval (drug interaction) ( 23459443) Response to radiotherapy in cancer (late toxicity) ( 24785509) Smoking status (heavy vs never) ( 26423011) Ulcerative colitis ( 26192919) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Ankylosing spondylitis ( 23749187) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 20351715) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23535729 20453838) Brown vs. black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cobalt levels ( 26025379) Colorectal cancer ( 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 25489960 28067908 21102463) Crohn's disease and psoriasis ( 22482804) Granulocyte count ( 27863252) Height ( 25282103 25429064 23563607 31562340) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte percentage of white cells ( 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (drugs used in diabetes) ( 31015401) Multiple sclerosis ( 31604244 22190364 24076602 19525953 21833088) Neutrophil percentage of white cells ( 27863252) Pediatric autoimmune diseases ( 26301688) Platelet distribution width ( 27863252) Prostate cancer ( 31562322) Psoriasis ( 25854761 23143594) Psoriasis vulgaris ( 26626624) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triiodothyronine/thyroxine ratio ( 30824882) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 31118516 30718926 28869590) Urate levels ( 31578528) Vitiligo ( 20526339) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		8 interacting genes: CASK CNTN2 CTR9 EPB41L3 KCNA2 MACF1 MEOX2 ZMIZ1	5 interacting genes: AR CACHD1 CNTNAP2 PIAS3 TBC1D4
Entrez ID		26047	57178
HPRD ID		05197	12115
Ensembl ID		ENSG00000174469	ENSG00000108175
Uniprot IDs		A0A090N7T7 B2RCH4 Q9UHC6	A0A024QZN6 A0JLS3 Q9ULJ6
PDB IDs		5Y4M	5AIZ
Enriched GO Terms of Interacting Partners?
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