BSG and MMP1

Number of citations of the paper that reports this interaction (PubMedID 10706100)
27

Data Source:
HPRD (in vitro, in vivo)

		BSG	MMP1
Description		basigin (Ok blood group)	matrix metallopeptidase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Membrane Axon Sarcolemma Melanosome Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome	Extracellular Region Extracellular Matrix
	Molecular Function	Protein Binding Mannose Binding Cadherin Binding Cell-cell Adhesion Mediator Activity	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding
	Biological Process	Pyruvate Metabolic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Response To Mercury Ion Decidualization Leukocyte Migration Response To CAMP Dendrite Self-avoidance Protein Localization To Plasma Membrane	Proteolysis Viral Process Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Complex Assembly Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Degradation of the extracellular matrix Basigin interactions Integrin cell surface interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Pyruvate metabolism	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling
Drugs			Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases			Choriocarcinoma
GWAS		Alzheimer's disease (late onset) ( 28714976)	Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		12 interacting genes: CAV1 CRBN HGS MMP1 PDLIM7 PPIA PPIL2 PPP2R1B SLC16A1 SLC16A3 SLC2A4 UBC	17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		682	4312
HPRD ID		00176	00384
Ensembl ID		ENSG00000172270	ENSG00000196611
Uniprot IDs		P35613 Q54A51	B4DN15 P03956 Q53G95
PDB IDs		3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0	1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?
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