MMP1 and ITGA2

Number of citations of the paper that reports this interaction (PubMedID 11359786)
46

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		MMP1	ITGA2
Description		matrix metallopeptidase 1	integrin subunit alpha 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Nucleus Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	Amyloid-beta Binding Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Proteolysis Viral Process Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Complex Assembly Cellular Protein Metabolic Process Leukocyte Migration	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Blood Coagulation Cell Proliferation Animal Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Viral Entry Into Host Cell Focal Adhesion Assembly Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation Response To Parathyroid Hormone Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058)	Acne (severe) ( 24927181) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Type 2 diabetes ( 30130595)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	14 interacting genes: ACTA1 APP AUP1 CD9 COL1A1 COL1A2 COL8A1 FBN2 HSPG2 ITGB1 LAMA1 MMP1 RABIF TSC22D2
Entrez ID		4312	3673
HPRD ID		00384	01893
Ensembl ID		ENSG00000196611	ENSG00000164171
Uniprot IDs		B4DN15 P03956 Q53G95	P17301
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	1AOX 1DZI 1PQB 1V7P 4BJ3 5HJ2 5THP 6ND8 6ND9 6NDA 6NDB 6NDC 6NDD 6NDE 6NDF 6NDG 6NDH
Enriched GO Terms of Interacting Partners?
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