STXBP1 and DOC2A

Number of citations of the paper that reports this interaction (PubMedID 9115738)
49

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		STXBP1	DOC2A
Description		syntaxin binding protein 1	double C2 domain alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleoplasm Nucleolus Lysosome Cell Junction Neuron Projection Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Negative Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis	Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion
Pathways		Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Whole brain grey matter density ( 31530798)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		31 interacting genes: APBA1 APBA2 APP C19orf57 CDK5 CDK5R1 DOC2A DOC2B HGS MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPTBN1 SQSTM1 STOM STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1	5 interacting genes: DYNLT1 RAP1GDS1 STXBP1 UBASH3B UNC13B
Entrez ID		6812	8448
HPRD ID		04235	05195
Ensembl ID		ENSG00000136854	ENSG00000149927
Uniprot IDs		P61764	Q14183
PDB IDs			4MJJ
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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