STXBP1 and NEFM

Number of citations of the paper that reports this interaction (PubMedID 12963086)
14

Data Source:
HPRD (in vivo)

		STXBP1	NEFM
Description		syntaxin binding protein 1	neurofilament medium
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse	Neurofilament Axon Intermediate Filament Cytoskeleton Neurofibrillary Tangle
	Molecular Function	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding
	Biological Process	Platelet Degranulation Developmental Process Involved In Reproduction Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Negative Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis	Neurofilament Bundle Assembly
Pathways		Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Whole brain grey matter density ( 31530798)	Fear of minor pain ( 28701861) Idiopathic dilated cardiomyopathy ( 29495422) Interleukin-6 levels ( 22205395) Metabolite levels ( 23823483)
Interacting Genes		31 interacting genes: APBA1 APBA2 APP C19orf57 CDK5 CDK5R1 DOC2A DOC2B HGS MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPTBN1 SQSTM1 STOM STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1	10 interacting genes: APOE DISC1 DRD2 FOS MINK1 NEFH RB1 SMAD2 STXBP1 TNIK
Entrez ID		6812	4741
HPRD ID		04235	01205
Ensembl ID		ENSG00000136854	ENSG00000104722
Uniprot IDs		P61764	P07197 Q9UK51
PDB IDs
Enriched GO Terms of Interacting Partners?
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