SPTBN1 and PLCB1

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		SPTBN1	PLCB1
Description		spectrin beta, non-erythrocytic 1	phospholipase C beta 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Extracellular Exosome Glutamatergic Synapse	Nuclear Chromatin Cell Nucleus Cytoplasm Cytosol Nuclear Speck Nuclear Membrane Protein-containing Complex Extracellular Exosome Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding GTPase Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Lamin Binding Phosphatidylinositol-4,5-bisphosphate Binding Enzyme Binding Identical Protein Binding
	Biological Process	MAPK Cascade Mitotic Cytokinesis ER To Golgi Vesicle-mediated Transport Plasma Membrane Organization Cytoskeleton Organization Common-partner SMAD Protein Phosphorylation Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Positive Regulation Of Interleukin-2 Secretion Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	G2/M Transition Of Mitotic Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Lipid Catabolic Process Cerebral Cortex Development Positive Regulation Of Interleukin-12 Production Inositol Trisphosphate Biosynthetic Process Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Fat Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Phosphatidylinositol Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Developmental Growth Release Of Sequestered Calcium Ion Into Cytosol Activation Of Meiosis Involved In Egg Activation Interleukin-1-mediated Signaling Pathway Regulation Of Fertilization Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Acrosome Reaction Negative Regulation Of Monocyte Extravasation Positive Regulation Of CD24 Biosynthetic Process
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	PLC beta mediated events PLC beta mediated events Synthesis of IP3 and IP4 in the cytosol Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (q) signalling events G beta:gamma signalling through PLC beta Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Presynaptic function of Kainate receptors
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bone mineral density (spine) ( 19079262 19801982 18445777) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Intraocular pressure ( 29617998 29785010 31959993 30054594 30591961) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Myopia (pathological) ( 22685421) Pars triangularis volume ( 31530798) Urate levels ( 31578528)	Adverse response to drug ( 30420678) Chronic kidney disease ( 26420894) Cognitive performance ( 20125193 19734545) Colorectal cancer ( 23263487) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 28135244) Estimated glomerular filtration rate ( 31152163 31451708) Lateral ventricle temporal horn volume ( 31530798) Lymphocyte counts ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 27863252) Neuritic plaque ( 31497858) Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Response to irinotecan in non-small-cell lung cancer ( 22664479) Social communication problems ( 24564958) Suicide ideation score in major depressive disorder ( 26079190) White blood cell count ( 27863252)
Interacting Genes		47 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 EIF3H EPB41 EPB41L3 GOLGA6L10 GRB2 GRIA2 HSPB1 MAPK14 MEF2C NF2 NOP53 PACSIN1 PJA1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 STXBP1 THAP3 TNIK TRAF3IP1 YWHAG ZNF251 ZNF512B	18 interacting genes: CEP76 CTBP1 CTBP2 GNAQ GRK2 MAPK1 MAPK3 PARD3 PARD6A PRKCA PRKCD RGS12 RGS4 SLC9A3R1 SPTBN1 TFCP2 TRPC3 TRPM7
Entrez ID		6711	23236
HPRD ID		01683	06177
Ensembl ID		ENSG00000115306	ENSG00000182621
Uniprot IDs		B2ZZ89 Q01082	Q9NQ66
PDB IDs		1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?
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