SPTBN1 and CTNNA1

Number of citations of the paper that reports this interaction (PubMedID 11069925)
25

Data Source:
BioGRID (pull down)

		SPTBN1	CTNNA1
Description		spectrin beta, non-erythrocytic 1	catenin alpha 1
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Extracellular Exosome Glutamatergic Synapse	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Flotillin Complex Lamellipodium Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding GTPase Binding	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	MAPK Cascade Mitotic Cytokinesis ER To Golgi Vesicle-mediated Transport Plasma Membrane Organization Cytoskeleton Organization Common-partner SMAD Protein Phosphorylation Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Positive Regulation Of Interleukin-2 Secretion Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	Ovarian Follicle Development Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Bone mineral density (spine) ( 19079262 19801982 18445777) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Intraocular pressure ( 29617998 29785010 31959993 30054594 30591961) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Myopia (pathological) ( 22685421) Pars triangularis volume ( 31530798) Urate levels ( 31578528)	General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061)
Interacting Genes		47 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 EIF3H EPB41 EPB41L3 GOLGA6L10 GRB2 GRIA2 HSPB1 MAPK14 MEF2C NF2 NOP53 PACSIN1 PJA1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 STXBP1 THAP3 TNIK TRAF3IP1 YWHAG ZNF251 ZNF512B	31 interacting genes: ACTN1 AFDN AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 DLG1 JUP LRATD2 MTNR1A MTNR1B OBI1 PKD1 PSEN1 SASH1 SPTAN1 SPTBN1 TJP1 TJP2 UBE2I VCL ZGPAT
Entrez ID		6711	1495
HPRD ID		01683	00285
Ensembl ID		ENSG00000115306	ENSG00000044115
Uniprot IDs		B2ZZ89 Q01082	A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221
PDB IDs		1AA2 1BKR 3EDV	1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?
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