SP4 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SP4	NRF1
Description		Sp4 transcription factor	nuclear respiratory factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleic Acid-templated Transcription	Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756) General cognitive ability ( 29844566) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		16 interacting genes: - ADAM15 ATXN7L1 BANP CIB3 COL8A1 E2F1 FOXP2 LMO3 NKX3-1 NRF1 POU2F1 PRR20A SERF2 SP1 ZBTB7A	13 interacting genes: CSNK2A1 DYNLL1 FHL2 LHX4 MAFF PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SP4 TRAF2
Entrez ID		6671	4899
HPRD ID		02764	02930
Ensembl ID		ENSG00000105866	ENSG00000106459
Uniprot IDs		A0A3B3IRW4 Q02446 Q32M51	A0A024R770 A0A024R774 Q16656
PDB IDs
Enriched GO Terms of Interacting Partners?
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