NRF1 and PPRC1

Number of citations of the paper that reports this interaction (PubMedID 11340167)
108

Data Source:
HPRD (in vitro, in vivo)

		NRF1	PPRC1
Description		nuclear respiratory factor 1	PPARG related coactivator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity	Transcription Coregulator Activity RNA Binding Transcription Factor Binding Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II	Mitochondrion Organization Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)	Mean corpuscular hemoglobin ( 27863252) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: CSNK2A1 DYNLL1 FHL2 LHX4 MAFF PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SP4 TRAF2	2 interacting genes: MCPH1 NRF1
Entrez ID		4899	23082
HPRD ID		02930	15173
Ensembl ID		ENSG00000106459	ENSG00000148840
Uniprot IDs		A0A024R770 A0A024R774 Q16656	E7EVG6 Q5VV67
PDB IDs
Enriched GO Terms of Interacting Partners?
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