SLC22A4 and PDZD3

Number of citations of the paper that reports this interaction (PubMedID 15553237)
12

Data Source:
HPRD (two hybrid)

		SLC22A4	PDZD3
Description		solute carrier family 22 member 4	PDZ domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Cation:cation Antiporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding
	Biological Process	Triglyceride Metabolic Process Sodium Ion Transport Body Fluid Secretion Carnitine Metabolic Process Organic Cation Transport Quaternary Ammonium Group Transport Carnitine Transport Carnitine Transmembrane Transport	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity
Pathways		Organic cation transport	Intestinal infectious diseases
Drugs		L-Carnitine
Diseases		Crohn's disease
GWAS		Acylcarnitine levels ( 26068415) Asthma ( 31619474) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Coronary artery disease ( 29212778) Crohn's disease ( 28067908 22412388 21102463) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 20031577) Fibrinogen levels ( 26561523) Granulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Mean platelet volume ( 27863252) Metabolic traits ( 21886157) Monocyte count ( 27863252) Myeloid white cell count ( 27863252) Nasal polyps ( 30643255) Neutrophil count ( 27863252) Serum metabolite levels ( 23093944) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: PDZD3 PDZK1 PVR SLC9A3R1 SLC9A3R2	18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7
Entrez ID		6583	79849
HPRD ID		09171	06191
Ensembl ID		ENSG00000197208	ENSG00000172367
Uniprot IDs		Q9H015	B0YJ61 Q86UT5
PDB IDs			2V90
Enriched GO Terms of Interacting Partners?
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