PDZD3 and CACNA1S

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PDZD3	CACNA1S
Description		PDZ domain containing 3	calcium voltage-gated channel subunit alpha1 S
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine
Pathways		Intestinal infectious diseases	NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Isradipine Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium Sulfate Verapamil Ethanol Felodipine Nitrendipine Nifedipine Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Manidipine
Diseases			Hypokalemic periodic paralysis (HypoPP)
GWAS			Cardiac Troponin-T levels ( 31014085) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Inflammatory bowel disease ( 28067908) Permanent tooth development ( 21931568) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	4 interacting genes: PDZD3 RIMS2 RYR1 SRI
Entrez ID		79849	779
HPRD ID		06191	00248
Ensembl ID		ENSG00000172367	ENSG00000081248
Uniprot IDs		B0YJ61 Q86UT5	B1ALM3 Q13698
PDB IDs		2V90	2VAY 6B27
Enriched GO Terms of Interacting Partners?
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