BMPR1A and BMP6

Number of citations of the paper that reports this interaction (PubMedID 10504300)
63

Data Source:
HPRD (in vivo)

		BMPR1A	BMP6
Description		bone morphogenetic protein receptor type 1A	bone morphogenetic protein 6
Image
GO Annotations	Cellular Component	Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Extracellular Space Cell Cytoplasm Vesicle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity	Cytokine Activity Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Stem Cell Population Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Heart Formation BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Response To Glucocorticoid Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Multicellular Organismal Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion
Pathways		Signaling by BMP
Drugs
Diseases		Hereditary mixed polyposis syndrome Juvenile polyposis syndrome
GWAS			Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Pulse pressure ( 27841878 30578418) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730)
Interacting Genes		25 interacting genes: ACVR1 BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 FKBP1A FKBP1B GDF5 GDF6 GDF9 HOXC8 NEDD4 NEDD4L OTUB1 SF3B4 SMAD1 TAB1 TDGF1 TGFBRAP1 USP15 ZMYND11	11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1 TDGF1
Entrez ID		657	654
HPRD ID		03192	00211
Ensembl ID		ENSG00000107779	ENSG00000153162
Uniprot IDs		P36894	B4DUF7 P22004 Q4VBA3
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4	2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?
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