BMP6 and BMPER

Number of citations of the paper that reports this interaction (PubMedID 12897139)
76

Data Source:
HPRD (in vivo)

		BMP6	BMPER
Description		bone morphogenetic protein 6	BMP binding endothelial regulator
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Cytoplasm Vesicle	Extracellular Space
	Molecular Function	Cytokine Activity Growth Factor Activity Protein Heterodimerization Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Eye Development Kidney Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Type B Pancreatic Cell Development Cellular Iron Ion Homeostasis Inflammatory Response Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Response To Activity Positive Regulation Of Bone Mineralization BMP Signaling Pathway Male Genitalia Development Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Aldosterone Biosynthetic Process Response To Retinoic Acid Positive Regulation Of Vascular Permeability Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Response To Glucocorticoid Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Multicellular Organismal Iron Ion Homeostasis Cellular Response To Mechanical Stimulus Cellular Response To Iron Ion Cellular Response To BMP Stimulus Negative Regulation Of Adherens Junction Organization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Aldosterone Secretion	Ureteric Bud Development Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Endothelial Cell Migration Negative Regulation Of BMP Signaling Pathway Endothelial Cell Activation Inner Ear Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Sprouting Angiogenesis
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Pulse pressure ( 27841878 30578418) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Small cell lung carcinoma ( 28604730)	Alzheimer's disease ( 24770881) Asthma ( 29273806) Corneal astigmatism ( 29422769) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Post bronchodilator FEV1 ( 26634245) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		11 interacting genes: ACVR1 ACVR2A BMPER BMPR1A BMPR1B BMPR2 CHRDL2 NCOA3 SMAD5 SOSTDC1 TDGF1	3 interacting genes: BMP2 BMP4 BMP6
Entrez ID		654	168667
HPRD ID		00211	16368
Ensembl ID		ENSG00000153162	ENSG00000164619
Uniprot IDs		B4DUF7 P22004 Q4VBA3	A0A090N7U6 A0A3B3ITW7 Q8N8U9
PDB IDs		2QCW 2R52 2R53 6OMO
Enriched GO Terms of Interacting Partners?
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