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SLC9A1 and WNK1
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
85
Data Source:
BioGRID
(two hybrid)
SLC9A1
WNK1
Description
solute carrier family 9 member A1
WNK lysine deficient protein kinase 1
Image
GO Annotations
Cellular Component
Cell
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Intercalated Disc
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lamellipodium
T-tubule
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cation-transporting ATPase Complex
Cytoplasm
Cytosol
Membrane
Molecular Function
Protein Binding
Calmodulin Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Solute:proton Antiporter Activity
Sodium:proton Antiporter Activity
Potassium:proton Antiporter Activity
Protein Phosphatase 2B Binding
Protein Binding, Bridging
Calcium-dependent Protein Binding
Molecular Adaptor Activity
Sodium:proton Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Chloride Channel Inhibitor Activity
Potassium Channel Inhibitor Activity
Protein Kinase Binding
Phosphatase Binding
Protein Kinase Activator Activity
Biological Process
Ion Transport
Cellular Sodium Ion Homeostasis
Regulation Of PH
Response To Acidic PH
Positive Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Cell Migration
Maintenance Of Cell Polarity
Hyaluronan Catabolic Process
Positive Regulation Of Cell Growth
Cellular Response To Insulin Stimulus
Positive Regulation Of Mitochondrial Membrane Permeability
Response To Muscle Stretch
Sodium Ion Export Across Plasma Membrane
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Action Potential
Positive Regulation Of Transcription By RNA Polymerase II
Protein Complex Oligomerization
Regulation Of Intracellular PH
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Regulation Of Sensory Perception Of Pain
Cardiac Muscle Cell Differentiation
Cellular Response To Cold
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Neuron Death
Cellular Response To Antibiotic
Cellular Response To Electrical Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Hypoxia
Cellular Response To Acidic PH
Potassium Ion Transmembrane Transport
Cellular Response To Epinephrine Stimulus
Cardiac Muscle Cell Contraction
Regulation Of Cardiac Muscle Cell Membrane Potential
Regulation Of The Force Of Heart Contraction By Cardiac Conduction
Anion Transmembrane Transport
Sodium Ion Import Across Plasma Membrane
Positive Regulation Of The Force Of Heart Contraction
Proton Transmembrane Transport
Positive Regulation Of Calcium:sodium Antiporter Activity
Regulation Of Sodium Ion Transport
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Ion Transport
Negative Regulation Of Sodium Ion Transport
Positive Regulation Of T Cell Chemotaxis
Negative Regulation Of Phosphatase Activity
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Signal Transduction By Trans-phosphorylation
Activation Of Protein Kinase Activity
Positive Regulation Of Ion Transmembrane Transporter Activity
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of GTPase Activity
Intracellular Signal Transduction
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Neuron Development
Regulation Of Cellular Process
Ion Homeostasis
T Cell Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Lymphocyte Migration Into Lymph Node
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Potassium Ion Import
Cellular Response To Chemokine
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Hyaluronan uptake and degradation
Sodium/Proton exchangers
Stimuli-sensing channels
Drugs
Amiloride
Homoserine Lactone
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Lateral ventricle volume (
31530798
)
Blood protein levels (
29875488
)
Body mass index (
25673413
29273807
)
Eosinophil counts (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Manganese levels (
26025379
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Squamous cell lung carcinoma (
28604730
)
Stroke (
19369658
)
Interacting Genes
12 interacting genes:
CA2
CHP1
CHP2
DAXX
MAP3K14
MAP4K4
MAPK1
MAPK14
MDFI
TESC
WNK1
YWHAB
35 interacting genes:
ADRB2
AKT1
ARAF
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
KLHL3
MAP2K1
MAP3K2
MAP3K3
MT-ATP8
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
SLC9A1
SYT2
TNRC6A
TSC22D1
UBE2I
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
Entrez ID
6548
65125
HPRD ID
00123
05570
Ensembl ID
ENSG00000090020
ENSG00000060237
Uniprot IDs
B2RAH2
P19634
A5D8Z4
F5GWT4
Q9H4A3
PDB IDs
1Y4E
2BEC
2E30
2HTG
2KBV
2L0E
2MDF
2YGG
6BJF
6NUC
6NUF
6NUU
4PWN
5TF9
5WDY
5WE8
6FBK
Enriched GO Terms of Interacting Partners
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