SLC8A1 and PPP3CB

Number of citations of the paper that reports this interaction (PubMedID 15557343)
12

Data Source:
HPRD (in vivo, two hybrid)

		SLC8A1	PPP3CB
Description		solute carrier family 8 member A1	protein phosphatase 3 catalytic subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Mitochondrion Microtubule Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Intercalated Disc Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Dendritic Spine Dendritic Shaft Axon Terminus Synapse Integral Component Of Postsynaptic Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule Glutamatergic Synapse
	Molecular Function	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Ankyrin Binding Ion Channel Binding Ion Antiporter Activity Involved In Regulation Of Postsynaptic Membrane Potential Calcium:cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Regulation Of Sodium Ion Transport Ion Transport Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Muscle Contraction Response To Glucose Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Fibroblast Migration Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Smooth Muscle Contraction Telencephalon Development Positive Regulation Of Bone Mineralization Response To ATP Sodium Ion Transmembrane Transport Response To Immobilization Stress Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Response To Hydrogen Peroxide Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Cytosolic Calcium Ion Transport Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To CAMP Cellular Response To Hypoxia Negative Regulation Of Protein Serine/threonine Kinase Activity Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction	Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Heart Development Learning Memory Dephosphorylation Calcium Ion Regulated Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Cellular Response To Drug Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis
Pathways		Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		Asthma ( 27611488) Chronotype ( 30696823) Diastolic blood pressure ( 28135244) Early spontaneous preterm birth ( 31194736) Electrocardiographic traits ( 25055868) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fractional exhaled nitric oxide levels ( 25431337) Fractures ( 30158200 30598549) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549 28869591) HIV-associated dementia ( 22628157) Immune response to measles-mumps-rubella vaccine ( 24811271) Mitochondrial DNA levels ( 25240745) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) PR interval ( 29127183 25035420) QT interval ( 29213071 24952745 22726844) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Total body bone mineral density ( 29304378)
Interacting Genes		6 interacting genes: CAV3 PPP3CB TRPC3 YWHAB YWHAE YWHAQ	17 interacting genes: AATK CABIN1 EGFR IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 ROR2 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		6546	5532
HPRD ID		01659	00235
Ensembl ID		ENSG00000183023	ENSG00000107758
Uniprot IDs		P32418 Q4QQH3	B7Z781 P16298
PDB IDs			4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?
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