PPP3CB and LMTK2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		PPP3CB	LMTK2
Description		protein phosphatase 3 catalytic subunit beta	lemur tyrosine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule Glutamatergic Synapse	Early Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Integral Component Of Membrane Growth Cone Neuronal Cell Body Receptor Complex Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding ATP Binding Myosin VI Binding
	Biological Process	Negative Regulation Of T Cell Mediated Cytotoxicity Lymphangiogenesis Protein Phosphorylation Protein Dephosphorylation Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Heart Development Learning Memory Dephosphorylation Calcium Ion Regulated Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Cellular Response To Drug Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis	Receptor Recycling Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Endocytic Recycling Negative Regulation Of Phosphoprotein Phosphatase Activity Transferrin Transport Positive Regulation Of Kinase Activity Early Endosome To Late Endosome Transport Protein Autophosphorylation
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation ROBO receptors bind AKAP5
Drugs
Diseases
GWAS			Gamma glutamyl transferase levels ( 29403010) Prostate cancer ( 18264097)
Interacting Genes		17 interacting genes: AATK CABIN1 EGFR IRAK1 IRF2 JUN LMTK2 MARCHF7 MYOZ2 MYOZ3 NFATC2 PTK7 ROR2 SLC8A1 SLC8A2 SLC8A3 SOCS3	24 interacting genes: CDC14A CDC25C CDK5 CDK5R1 DUPD1 DUSP14 DUSP19 DUSP6 ILKAP MTMR6 PPM1A PPM1F PPM1K PPP1CA PPP1CB PPP1CC PPP1R2 PPP3CB PTPDC1 PTPN12 PTPN6 PTPRR STYX TPTE2
Entrez ID		5532	22853
HPRD ID		00235	13994
Ensembl ID		ENSG00000107758	ENSG00000164715
Uniprot IDs		B7Z781 P16298	Q8IWU2
PDB IDs		4OR9 4ORA 4ORC
Enriched GO Terms of Interacting Partners?
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