SLC6A3 and PICK1

Number of citations of the paper that reports this interaction (PubMedID 11343649)
85

Data Source:
HPRD (two hybrid, in vivo)

		SLC6A3	PICK1
Description		solute carrier family 6 member 3	protein interacting with PRKCA 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Flotillin Complex Axon Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Neuronal Cell Body Membrane Raft Dopaminergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Dopamine Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Phosphatase 2A Binding	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity
	Biological Process	Transport Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Iron Ion Monoamine Transport Dopamine Transport Norepinephrine Transport Adenohypophysis Development Response To Nicotine Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Transmembrane Transport Prepulse Inhibition Dopamine Uptake	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Dopamine clearance from the synaptic cleft Na+/Cl- dependent neurotransmitter transporters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Atomoxetine Mirtazapine Loxapine Methylphenidate Pethidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorphenamine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Lisdexamfetamine Ephedra MMDA Midomafetamine Fencamfamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Vanoxerine Nomifensine Altropane Mianserin Armodafinil Dexmethylphenidate Dasotraline
Diseases
GWAS		Pancreatic cancer ( 25086665)	Body fat percentage ( 26833246)
Interacting Genes		9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1	47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7
Entrez ID		6531	9463
HPRD ID		00543	16176
Ensembl ID		ENSG00000142319	ENSG00000100151
Uniprot IDs		Q01959	A0A024R1J5 Q9NRD5
PDB IDs			2GZV 6AR4 6BJN 6BJO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?