SLC6A3 and TGFB1I1

Number of citations of the paper that reports this interaction (PubMedID 12177201)
35

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SLC6A3	TGFB1I1
Description		solute carrier family 6 member 3	transforming growth factor beta 1 induced transcript 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Flotillin Complex Axon Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Neuronal Cell Body Membrane Raft Dopaminergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Nuclear Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Dopamine Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Phosphatase 2A Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding
	Biological Process	Transport Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Iron Ion Monoamine Transport Dopamine Transport Norepinephrine Transport Adenohypophysis Development Response To Nicotine Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Transmembrane Transport Prepulse Inhibition Dopamine Uptake	Transcription By RNA Polymerase II Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Dopamine clearance from the synaptic cleft Na+/Cl- dependent neurotransmitter transporters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Atomoxetine Mirtazapine Loxapine Methylphenidate Pethidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorphenamine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Lisdexamfetamine Ephedra MMDA Midomafetamine Fencamfamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Vanoxerine Nomifensine Altropane Mianserin Armodafinil Dexmethylphenidate Dasotraline
Diseases
GWAS		Pancreatic cancer ( 25086665)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1	29 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL
Entrez ID		6531	7041
HPRD ID		00543	03831
Ensembl ID		ENSG00000142319	ENSG00000140682
Uniprot IDs		Q01959	A0A024QZE7 O43294
PDB IDs
Enriched GO Terms of Interacting Partners?
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