SLC6A2 and STX1A

Number of citations of the paper that reports this interaction (PubMedID 12629174)
51

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SLC6A2	STX1A
Description		solute carrier family 6 member 2	syntaxin 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Membrane Raft	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Endomembrane System Postsynaptic Density Integral Component Of Membrane Cell Junction Secretory Granule Integral Component Of Synaptic Vesicle Membrane Axon SNARE Complex Nuclear Membrane Actomyosin Presynaptic Membrane Neuron Projection Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Actin Binding Neurotransmitter:sodium Symporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding	SNARE Binding SNAP Receptor Activity Protein Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Myosin Head/neck Binding Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Transport Chemical Synaptic Transmission Monoamine Transport Norepinephrine Transport Response To Pain Dopamine Uptake Involved In Synaptic Transmission Norepinephrine Uptake Transmembrane Transport Neuron Cellular Homeostasis	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Exocytosis Vesicle Fusion Neurotransmitter Secretion Response To Gravity Positive Regulation Of Norepinephrine Secretion Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Protein Sumoylation Calcium Ion Regulated Exocytosis Cytokine-mediated Signaling Pathway Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Secretion By Cell Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Synaptic Vesicle Endocytosis Regulation Of Insulin Secretion Protein Localization To Membrane Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Na+/Cl- dependent neurotransmitter transporters Defective SLC6A2 causes orthostatic intolerance (OI)	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (BoNT/C) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Amphetamine Phentermine Tramadol Guanadrel Reboxetine Venlafaxine Atomoxetine Amitriptyline Protriptyline Mirtazapine Loxapine Methylphenidate Pethidine Imipramine Duloxetine Dextromethorphan Nortriptyline Amoxapine Mazindol Ergotamine Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Maprotiline Diethylpropion Dopamine Sibutramine Chlorphenamine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Ketamine Clomipramine Ephedra Ephedrine Ginkgo biloba MMDA Midomafetamine Dextroamphetamine Methamphetamine Phendimetrazine Nomifensine Amineptine Debrisoquin Bicifadine Milnacipran XEN2174 CRx-119 Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levomilnacipran Dosulepin Viloxazine Dasotraline
Diseases		Orthostatic intolerance (OI); Postural tachycardia syndrome (POTS)
GWAS		Birth weight ( 31043758) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		2 interacting genes: PPP2R1A STX1A	60 interacting genes: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEC22B SEPTIN2 SEPTIN5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS16 VPS18
Entrez ID		6530	6804
HPRD ID		01232	01721
Ensembl ID		ENSG00000103546	ENSG00000106089
Uniprot IDs		A0A024R6T9 H3BRE9 P23975	Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?
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