WNK4 and CLDN4

Number of citations of the paper that reports this interaction (PubMedID 15070779)
69

Data Source:
HPRD (in vivo, in vitro)

		WNK4	CLDN4
Description		WNK lysine deficient protein kinase 4	claudin 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Establishment Of Skin Barrier Renal Absorption Positive Regulation Of Wound Healing Chloride Transmembrane Transport Positive Regulation Of Metallopeptidase Activity
Pathways		Stimuli-sensing channels	Tight junction interactions
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Interacting Genes		11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	4 interacting genes: EPHA2 SHBG TJP1 WNK4
Entrez ID		65266	1364
HPRD ID		03505	04218
Ensembl ID		ENSG00000126562	ENSG00000189143
Uniprot IDs		Q96J92	O14493 Q75L80
PDB IDs		2V3S 4CH9 4CHB	5B2G
Enriched GO Terms of Interacting Partners?
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