CLDN4 and WNK4

Number of citations of the paper that reports this interaction (PubMedID 15070779)
69

Data Source:
HPRD (in vivo, in vitro)

		CLDN4	WNK4
Description		claudin 4	WNK lysine deficient protein kinase 4
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basal Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Chloride Channel Complex Tight Junction	Cytoplasm Cytosol Bicellular Tight Junction Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Structural Molecule Activity Chloride Channel Activity Protein Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity
	Biological Process	Female Pregnancy Circadian Rhythm Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Cell Morphogenesis Positive Regulation Of Cell Migration Response To Progesterone Establishment Of Skin Barrier Renal Absorption Positive Regulation Of Wound Healing Chloride Transmembrane Transport Positive Regulation Of Metallopeptidase Activity	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Tight junction interactions	Stimuli-sensing channels
Drugs
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Interacting Genes		4 interacting genes: EPHA2 SHBG TJP1 WNK4	11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39
Entrez ID		1364	65266
HPRD ID		04218	03505
Ensembl ID		ENSG00000189143	ENSG00000126562
Uniprot IDs		O14493 Q75L80	Q96J92
PDB IDs		5B2G	2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?
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