SKP2 and RND3

Number of citations of the paper that reports this interaction (PubMedID 24045951)
8

Data Source:
BioGRID (enzymatic study)

		SKP2	RND3
Description		S-phase kinase associated protein 2	Rho family GTPase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex	Golgi Membrane Cytoplasm Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Division Site Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Viral Process Protein Deubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination	Cytokinesis Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Actin Cytoskeleton Organization Actin Filament Bundle Assembly
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Guanosine-5'-Triphosphate
Diseases
GWAS		Birth weight ( 31043758) Metabolite levels ( 23823483) Red cell distribution width ( 27863252)	Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) Platelet count ( 31217584) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		62 interacting genes: AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 EP300 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NLK ORC1 PDCD4 PFDN1 PIM1 POLR2A PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SLC9A3R1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1	6 interacting genes: ARHGAP5 CIT PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		6502	390
HPRD ID		03256	04233
Ensembl ID		ENSG00000145604	ENSG00000115963
Uniprot IDs		A0A024R069 Q13309	B2R838 P61587
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST	1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?
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