CENPH and MTAP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CENPH	MTAP
Description		centromere protein H	methylthioadenosine phosphorylase
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Nucleolus Cytosol	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Kinetochore Binding	Phosphorylase Activity Purine-nucleoside Phosphorylase Activity Protein Binding S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Mitotic Spindle Organization Chromosome Segregation CENP-A Containing Nucleosome Assembly Kinetochore Assembly Kinetochore Organization	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone Interleukin-12-mediated Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Adenine (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol Formycin 5'-Deoxy-5'-Methylthioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases
GWAS			Adverse response to drug ( 30420678) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)
Interacting Genes		5 interacting genes: CENPK KIF2C MTAP NDC80 NUF2	6 interacting genes: CDC25A CENPH FOLH1 LYRM1 MYLIP RELB
Entrez ID		64946	4507
HPRD ID		12029	01134
Ensembl ID		ENSG00000153044	ENSG00000099810
Uniprot IDs		A0A0S2Z5T0 Q9H3R5	A0A384ME80 Q13126
PDB IDs			1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?
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