MTAP and FOLH1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MTAP	FOLH1
Description		methylthioadenosine phosphorylase	folate hydrolase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Phosphorylase Activity Purine-nucleoside Phosphorylase Activity Protein Binding S-methyl-5-thioadenosine Phosphorylase Activity	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Dipeptidase Activity Metal Ion Binding Ac-Asp-Glu Binding Tetrahydrofolyl-poly(glutamate) Polymer Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone Interleukin-12-mediated Signaling Pathway	Proteolysis Folic Acid-containing Compound Metabolic Process Cellular Amino Acid Biosynthetic Process C-terminal Protein Deglutamylation
Pathways		Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Aspartate and asparagine metabolism
Drugs		Adenine (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol Formycin 5'-Deoxy-5'-Methylthioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin	Capromab pendetide Glutamic Acid (2S)-2-{[HYDROXY(4-IODOBENZYL)PHOSPHORYL]METHYL}PENTANEDIOIC ACID N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid Spaglumic Acid
Diseases
GWAS		Adverse response to drug ( 30420678) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)	Blood protein levels ( 30072576) Feeling fed-up ( 29500382) HDL cholesterol ( 19060911) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960) Intraocular pressure ( 29617998) Systolic blood pressure ( 30578418) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		6 interacting genes: CDC25A CENPH FOLH1 LYRM1 MYLIP RELB	2 interacting genes: MTAP RPS3
Entrez ID		4507	2346
HPRD ID		01134	02961
Ensembl ID		ENSG00000099810	ENSG00000086205
Uniprot IDs		A0A384ME80 Q13126	Q04609
PDB IDs		1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3	1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBJ 2JBK 2OOT 2OR4 2PVV 2PVW 2XEF 2XEG 2XEI 2XEJ 3BHX 3BI0 3BI1 3BXM 3D7D 3D7F 3D7G 3D7H 3IWW 3RBU 3SJE 3SJF 3SJG 3SJX 4JYW 4JZ0 4LQG 4MCP 4MCQ 4MCR 4MCS 4NGM 4NGN 4NGP 4NGQ 4NGR 4NGS 4NGT 4OC0 4OC1 4OC2 4OC3 4OC4 4OC5 4OME 4P44 4P45 4P4B 4P4D 4P4E 4P4F 4P4I 4P4J 4W9Y 4X3R 5D29 5ELY 5F09 5O5R 5O5T 5O5U 5OF0 6ETY 6EZ9 6F5L 6FE5 6H7Y 6H7Z 6HKJ 6HKZ
Enriched GO Terms of Interacting Partners?
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