ST3GAL4 and GGCX

		ST3GAL4	GGCX
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 4	gamma-glutamyl carboxylase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Lipid Glycosylation Cognition Sialylation Protein Sialylation	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis N-Glycan antennae elongation Termination of O-glycan biosynthesis	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors
Drugs			Coagulation factor VIIa Recombinant Human Drotrecogin alfa Coagulation Factor IX (Recombinant) Glutamic Acid Menadione Phylloquinone Anisindione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Mean platelet volume ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 27863252) Platelet distribution width ( 27863252) Serum alkaline phosphatase levels ( 31666285 29403010) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 30275531) vWF levels ( 30586737)	Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Myocardial infarction ( 26343387) Prostate cancer ( 21743467)
Interacting Genes		3 interacting genes: ARHGDIA CD8B GGCX	14 interacting genes: ARFGAP1 ATP2C1 BGLAP CD8A F10 F2 F7 F9 FXN PDCD5 PPM1G PROC SRPK2 ST3GAL4
Entrez ID		6484	2677
HPRD ID		00084	00665
Ensembl ID		ENSG00000110080	ENSG00000115486
Uniprot IDs		Q11206 Q6IBE6	P38435
PDB IDs
Enriched GO Terms of Interacting Partners?
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