SRSF1 and YTHDC1

Number of citations of the paper that reports this interaction (PubMedID 9473574)
12

Data Source:
HPRD (two hybrid, in vitro)

		SRSF1	YTHDC1
Description		serine and arginine rich splicing factor 1	YTH domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck
	Molecular Function	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding	RNA Binding Protein Binding N6-methyladenosine-containing RNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome	MRNA Splice Site Selection MRNA Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Posttranscriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Copper
Diseases
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		40 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	35 interacting genes: ABL1 ADAMTS4 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 LAMC3 LAMTOR5 LZTS2 MPRIP PLG PROSER2 RBMY1F SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51
Entrez ID		6426	91746
HPRD ID		02887	11689
Ensembl ID		ENSG00000136450	ENSG00000083896
Uniprot IDs		Q07955 Q59FA2	J3QR07 Q96MU7
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O	2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7
Enriched GO Terms of Interacting Partners?
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