RRAGC and DEPDC5

Number of citations of the paper that reports this interaction (PubMedID 23723238)
302

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RRAGC	DEPDC5
Description		Ras related GTP binding C	DEP domain containing 5, GATOR1 subcomplex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol EGO Complex Intracellular Membrane-bounded Organelle Gtr1-Gtr2 GTPase Complex	Lysosome Lysosomal Membrane Cytosol Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Heterodimerization Activity GTPase Binding	GTPase Activator Activity Protein-containing Complex Binding
	Biological Process	Transcription, DNA-templated Apoptotic Process Cell Cycle Arrest Small GTPase Mediated Signal Transduction RNA Splicing Cellular Response To Starvation Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Response To Amino Acid Cellular Response To Amino Acid Stimulus Regulation Of TORC1 Signaling	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of TORC1 Signaling
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Blood protein levels ( 28240269)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Type 2 diabetes ( 30130595)
Interacting Genes		7 interacting genes: ATXN1L DEPDC5 MPP3 NOL8 RRAGA RRAGB WNT2	2 interacting genes: RRAGB RRAGC
Entrez ID		64121	9681
HPRD ID		12198	16795
Ensembl ID		ENSG00000116954	ENSG00000100150
Uniprot IDs		B4DQ03 B4DQG4 Q9HB90	O75140
PDB IDs		3LLU 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG	6CES 6CET
Enriched GO Terms of Interacting Partners?
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