DEPDC5 and RRAGB

Number of citations of the paper that reports this interaction (PubMedID 23723238)
302

Data Source:
BioGRID (pull down, affinity chromatography technology)

		DEPDC5	RRAGB
Description		DEP domain containing 5, GATOR1 subcomplex subunit	Ras related GTP binding B
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Cytosol EGO Complex Gtr1-Gtr2 GTPase Complex
	Molecular Function	GTPase Activator Activity Protein-containing Complex Binding	GTPase Activity Protein Binding GTP Binding Guanyl Ribonucleotide Binding GTPase Binding
	Biological Process	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of TORC1 Signaling	Cell Cycle Arrest Cellular Response To Starvation Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein Localization Cellular Response To Amino Acid Stimulus Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Type 2 diabetes ( 30130595)	Male-pattern baldness ( 27182965) Prostate-specific antigen levels ( 28139693) Smoking initiation ( 24665060)
Interacting Genes		2 interacting genes: RRAGB RRAGC	6 interacting genes: APP DEPDC5 MTOR RPTOR RRAGC RRAGD
Entrez ID		9681	10325
HPRD ID		16795	06710
Ensembl ID		ENSG00000100150	ENSG00000083750
Uniprot IDs		O75140	Q5VZM2
PDB IDs		6CES 6CET
Enriched GO Terms of Interacting Partners?
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