SDC2 and ITGB4

Number of citations of the paper that reports this interaction (PubMedID 20181947)
24

Data Source:
BioGRID (two hybrid)

		SDC2	ITGB4
Description		syndecan 2	integrin subunit beta 4
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix	Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration	Autophagy Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Mesodermal Cell Differentiation Cell Motility
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport	Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly
Drugs		Sargramostim	R1295
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Post-traumatic stress disorder ( 26114229)
Interacting Genes		27 interacting genes: ANOS1 BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4	25 interacting genes: ALOX12 ATXN1 CLCA1 CLCA2 COL17A1 DST EIF6 ERBB2 ERBIN FYN GRB2 ITGA6 MET PLEC PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 VIM YES1 YWHAB YWHAQ
Entrez ID		6383	3691
HPRD ID		00803	00946
Ensembl ID		ENSG00000169439	ENSG00000132470
Uniprot IDs		A0A024R9D1 E9PBI9 P34741	A0A024R8K7 A0A024R8N2 A0A024R8T0 B7ZLD8 P16144
PDB IDs		6ITH	1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL
Enriched GO Terms of Interacting Partners?
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