CCL17 and ACKR1

Number of citations of the paper that reports this interaction (PubMedID 13679391)
22

Data Source:
HPRD (in vivo)

		CCL17	ACKR1
Description		C-C motif chemokine ligand 17	atypical chemokine receptor 1 (Duffy blood group)
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GO Annotations	Cellular Component	Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity CCR4 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Monocyte Chemotaxis Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation Of Myoblast Differentiation Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines	Peptide ligand-binding receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269)	Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)
Interacting Genes		4 interacting genes: ACKR1 CCR4 CCR8 VCAM1	9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B
Entrez ID		6361	2532
HPRD ID		03309	00192
Ensembl ID		ENSG00000102970	ENSG00000213088
Uniprot IDs		Q92583	Q16570 Q5Y7A1 Q5Y7A2
PDB IDs		1NR2 1NR4 5WK3	4NUU 4NUV
Enriched GO Terms of Interacting Partners?
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