CCL16 and HRH4

Number of citations of the paper that reports this interaction (PubMedID 15265943)
14

Data Source:
HPRD (in vivo)

		CCL16	HRH4
Description		C-C motif chemokine ligand 16	histamine receptor H4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cell Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Protein Binding Chemokine Activity Chemoattractant Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Monocyte Chemotaxis Chemotaxis Inflammatory Response Cell Communication G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Positive Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Inflammatory Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Biological_process Regulation Of MAPK Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Histamine receptors G alpha (i) signalling events
Drugs			Amitriptyline Olanzapine Clozapine Loxapine Chlorpromazine Amoxapine Doxepin REV131 Histamine Mianserin
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Initial pursuit acceleration ( 29064472)	Chronotype ( 30696823) Response to taxane treatment (docetaxel) ( 23006423)
Interacting Genes		5 interacting genes: CCR1 CCR5 CCR8 HRH4 SDF2	4 interacting genes: CCL16 GNA15 GNAI1 GNAO1
Entrez ID		6360	59340
HPRD ID		03233	06004
Ensembl ID		ENSG00000275152	ENSG00000134489
Uniprot IDs		O15467	B2KJ49 Q9H3N8
PDB IDs		5LTL
Enriched GO Terms of Interacting Partners?
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