SCN3A and LRP8

Number of citations of the paper that reports this interaction (PubMedID 10827173)
122

Data Source:
BioGRID (two hybrid)

		SCN3A	LRP8
Description		sodium voltage-gated channel alpha subunit 3	LDL receptor related protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane Axon	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity	Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity
	Biological Process	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Cytokine-mediated Signaling Pathway Ammon Gyrus Development Cerebral Cortex Development Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Regulation Of Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Platelet sensitization by LDL Retinoid metabolism and transport
Drugs		Phenytoin Valproic Acid Zonisamide Tetrodotoxin Brivaracetam Lacosamide
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Epilepsy ( 30531953) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Metabolite levels ( 23823483) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Cerebrospinal fluid AB1-42 levels ( 28247064) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		5 interacting genes: CNTN1 LRP1 LRP2 LRP8 PRKCG	21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		6328	7804
HPRD ID		01671	04002
Ensembl ID		ENSG00000153253	ENSG00000157193
Uniprot IDs		A0A590UJH3 Q9C007 Q9NY46	A0A590UJ98 Q14114
PDB IDs			3A7Q 5B4X 5B4Y
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?