LRP8 and APBA2

Number of citations of the paper that reports this interaction (PubMedID 10827173)
122

Data Source:
BioGRID (two hybrid)

		LRP8	APBA2
Description		LDL receptor related protein 8	amyloid beta precursor protein binding family A member 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex	Cytoplasm Plasma Membrane Synaptic Vesicle Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity	Amyloid-beta Binding Protein Binding Identical Protein Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Cytokine-mediated Signaling Pathway Ammon Gyrus Development Cerebral Cortex Development Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Regulation Of Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development	In Utero Embryonic Development Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth Regulation Of Synaptic Vesicle Exocytosis
Pathways		Platelet sensitization by LDL Retinoid metabolism and transport	Neurexins and neuroligins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Cerebrospinal fluid AB1-42 levels ( 28247064) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)	Response to mTOR inhibitor (rapamycin) ( 24009623) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Temperament ( 22832960)
Interacting Genes		21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP	13 interacting genes: APP ARF3 ARF4 CLSTN1 CLSTN3 LRP1 LRP2 LRP8 MAPK6 NECAB3 NRXN1 RELA STXBP1
Entrez ID		7804	321
HPRD ID		04002	04090
Ensembl ID		ENSG00000157193	ENSG00000034053
Uniprot IDs		A0A590UJ98 Q14114	Q59G28 Q99767
PDB IDs		3A7Q 5B4X 5B4Y
Enriched GO Terms of Interacting Partners?
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