CFB and LAMTOR5

Number of citations of the paper that reports this interaction (PubMedID 23241634)
1

Data Source:
BioGRID (two hybrid)

		CFB	LAMTOR5
Description		complement factor B	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome Blood Microparticle	Lysosome Lysosomal Membrane Cytosol Ragulator Complex
	Molecular Function	Complement Binding Serine-type Endopeptidase Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Proteolysis Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade	Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Zinc 4-Guanidinobenzoic Acid Diisopropylphosphono Group
Diseases		Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23577725 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576 29875488 28240269) Chronic hepatitis B infection ( 25802187) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Height ( 28552196) Hematology traits ( 23263863) Inflammatory bowel disease ( 28067908) Prostate cancer ( 23535732) Rosacea symptom severity ( 29771307) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908)
Interacting Genes		5 interacting genes: C3 CFP LAMC3 LAMTOR5 RPA2	32 interacting genes: ALB ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLCC1 DBI EEF1A1 GAPDH GIT1 GPRASP1 LAMTOR4 LRIF1 MAF1 MCPH1 MEOX2 MT2A NCOA6 PDK1 RABIF RBP4 SERPINA1 TAF9 TGFB1 TOP2B TP53 UTP14A YTHDC1 ZBTB16
Entrez ID		629	10542
HPRD ID		00718	09773
Ensembl ID		ENSG00000243649	ENSG00000134248
Uniprot IDs		A0A1U9X7H8 P00751	A0A0C4DGV4 O43504
PDB IDs		1DLE 1Q0P 1RRK 1RS0 1RTK 2OK5 2WIN 2XWB 2XWJ 3HRZ 3HS0 6QSW 6QSX 6RAV 6RUR 6RUV	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG
Enriched GO Terms of Interacting Partners?
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